Tofacitinib CAS:477600-75-2 Mugadziri Mutengesi

Tofacitinib mushonga wekurapa rheumatoid arthritis (RA), psoriasis, inflammatory bowel chirwere, uye zvimwe zvirwere zveimmunological, pamwe nekudzivirira kurambwa kwenhengo.Iyo inhibitor ye enzyme Janus kinase 3 (JAK3), zvinoreva kuti inovhiringa nzira yekusaina yeJAK-STAT inotumira ruzivo kunze kwesero mukati mesero nucleus, ichipesvedzera kunyorwa kweDNA.Munguva pfupi yapfuura yakaratidzwa mumurine muenzaniso weArthritis yakasimbiswa, tofacitinib yakakurumidza kuvandudzwa chirwere nekudzivisa kugadzirwa kwevamiririri vanopisa uye kudzvinyirira STAT1-inotsamira majini muhutano hwekubatana.Kubudirira uku mumuenzaniso wechirwere ichi kwakabatana nekudzivisa kwezvose JAK1 uye 3 chiratidzo. nzira, zvichiratidza kuti tofacitinib inogona kushandisa rubatsiro rwekurapa kuburikidza nenzira dzisiri dzega kuvharisa kweJAK3.