Tofacitinib CAS:477600-75-2 Mugadziri weMugadziri Mufananidzo Wakaratidzwa

Tofacitinib CAS:477600-75-2 Mugadziri wezvinhu

Tofacitinib ndiyo yekutanga diki molecule kinase inhibitor yakatenderwa kurapa RA. Tofacitinib inhibitor yemarudzi mana eJanus kinase (JAK): JAK1, JAK2, JAK3, naTyk2. Tofacitinib inoshanda nekudzivisa phosphorylation uye activation yesignal transducers uye activators of transcription (STATs), nokudaro ichidzvinyirira kugadzirwa kwezvinokonzera kuzvimba mumatishu ejoini.

Odha kana Kumbira Mutengo

Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Kushandiswa uye Mhedzisiro

Tofacitinib mushonga wekurapa rheumatoid arthritis (RA), psoriasis, chirwere chemudumbu chinoputika, nezvimwe zvirwere zvemuviri, pamwe nekudzivirira kurambwa kwenhengo. Inodzivirira enzyme Janus kinase 3 (JAK3), zvinoreva kuti inokanganisa nzira yeJAK-STAT signaling iyo inotumira ruzivo kunze kwesero kuenda kunucleus yesero, zvichikanganisa kunyorwa kweDNA. Munguva pfupi yapfuura yakaratidzwa mumuenzaniso wemurine wearthritis, tofacitinib inokurumidza kugadzirisa chirwere nekudzivisa kugadzirwa kwevanorwisa uye kudzvinyirira majini anoenderana neSTAT1 mumatishu ejoini. Kushanda uku mumuenzaniso wechirwere ichi kwakabatana nekudziviswa kwenzira dzese dzeJAK1 ne3 signaling, zvichiratidza kuti tofacitinib inogona kubatsira pakurapa kuburikidza nenzira dzisiri dzekudzivirira JAK3 chete.

Muenzaniso weChigadzirwa

Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	C16H20N6O
Kuyedza	99%
Chitarisiko	Upfu husina kuchena
Nhamba yeCAS	477600-75-2
Kurongedza	25KG
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.