β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

NAD+ inokosha zvikuru mukushanda kwemasero uye yakawana kufarira munzvimbo dzakadai sekutsvaga kwekukwegura, metabolism, uye hutano hwemasero. Se coenzyme, NAD+ inobatanidzwa mukuita kwe redox kwakakosha pakugadzirwa kwesimba mukati me mitochondria, ichitsigira maitiro akadai se glycolysis, tricarboxylic acid cycle, uye oxidative phosphorylation. Pamusoro pezvo, NAD+ inoshanda se substrate yema enzymes akadai se sirtuins nePARPs, ayo anobatanidzwa mukugadzirisa DNA, kugadzirisa maitiro e gene, uye nzira dzemhinduro yekushushikana kwemasero. Mumakore achangopfuura, NAD+ precursors, dzakadai se nicotinamide riboside (NR) uye nicotinamide mononucleotide (NMN), dzakawana kutariswa sedzimwe nzira dzinogona kutsigira mazinga eNAD+ mukati memasero. Tsvagiridzo inoratidza kuti kuchengetedza mazinga eNAD+ akakodzera kunogona kuita basa mu mitochondrial biogenesis, metabolic homeostasis, uye hupenyu hurefu. Nekuda kweizvozvo, NAD+ precursors dziri kuferefetwa kuti dzikwanise kuderedza kudzikira kunoenderana nekukwegura, kutsigira kukwegura kwakanaka, uye kugadzirisa kusawirirana kwemetabolic kunoenderana nemamiriro akaita sekufutisa nechirwere cheshuga. Uyezve, NAD+ inzvimbo iri kufarirwa zvakanyanya mumitambo nemuviri wekurovedza muviri nekuda kwekubatanidzwa kwayo mukushandiswa kwesimba mumuviri uye kushanda kwemitochondrial. Zvidzidzo zvekuongorora kushanduka kweNAD+ maererano nekushanda kwemuviri, kupora kwetsandanyama, uye kugona kutsungirira zviri kuenderera mberi, zvichikonzera mhedzisiro pakushanda kwemitambo uye kugona kutsungirira. Kazhinji, NAD+ nezvinotangira zvayo zvinomiririra nzvimbo inoshanda yekuferefeta kwesainzi ine mashandisirwo anogona kusanganisira kukwegura, hutano hwemasero, metabolism, uye muviri wemuviri wekurovedza muviri, zvichiratidza mamiriro akafara uye ari kuchinja ekutsvagisa uye kukosha kwekurapa.