2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE CAS:407-38-5

2,2,2-Trifluoroethyl trifluoroacetate (TFETA) imusanganiswa une hunyanzvi hwakasiyana une hunyanzvi hwemakemikari hunobatsira mukushandiswa kwayo kwakakura mumaindasitiri akasiyana-siyana. Hunhu TFETA inoratidzwa nechimiro chayo chemamorekuru, ine boka retrifluoroethyl (-CF3CH2-) rakabatanidzwa kune trifluoroacetate ester (-OC(O)CF3). Musanganiswa uyu unoguma nemvura yakajeka, isina ruvara ine poindi yakawanda yekufashaira, inosvika 145°C, uye inonyungudika zvakanaka muzvinhu zvakasikwa. Musanganiswa uyu unoratidza reactivity yakaderera nekuda kwehunhu hwemaatomu efluorine anobvisa maerekitironi, zvichipa kugadzikana kwakasimba kwemakemikari pasi pemamiriro akasiyana-siyana. Hunhu hweTFETA hunoita kuti ive yakakodzera kushandiswa kunoda kusagadzikana, senge mukugadzirwa kwezvikamu zvakagadzikana uye zvinodzivirira. Mashandisirwo Organic Synthesis: TFETA inoshanda sepakati yakakosha mukugadzirwa kweorganic, uko inobatanidzwa mukuita kwekuita kuti fluorinated functionalities ive mumamorekuru akaoma. Kugona uku kunonyanya kukosha mumakemikari emishonga ekugadzira mishonga ine fluorinated uye mukugadzirwa kwemakemikari akakosha uko kugadzikana kwakawedzerwa uye kuramba kwemakemikari kunodiwa. Sainzi Yezvinhu: Kugadzikana kwemakemikari uye kunyungudika kweTFETA kunoita kuti ive chinhu chakakodzera mukugadzirwa kwezvipfeko nezvinhu zvine zvinodiwa zvekushanda. Inoshandiswa kuwedzera kugara kwenguva refu uye hunhu hwekudzivirira hwenzvimbo kubva pakuora kwezvakatipoteredza uye kurwiswa kwemakemikari, zvichibatsira kuti zvinhu zvigare kwenguva refu mukushandiswa kubva pazvipfeko zvemotokari kusvika kuzvinhu zvemagetsi. Mashandisirwo Emishonga: Basa reTFETA mukugadzirwa kwezvinhu zvakasikwa rinowedzera kusvika kukushandiswa kwemishonga, uko chimiro chayo chefluorinated chinogona kugadzirisa mashandiro ehupenyu uye hunhu hwe pharmacokinetic hwemamorekuru emishonga. Izvi zvinoita kuti ive chishandiso chakakosha mukuwana mishonga nekugadzira maitiro akagadzirirwa kuvandudza kushanda kwekurapa uye bioavailability. Kugadzirwa kweTFETA kunogadzirwa kuburikidza ne esterification ye trifluoroacetic acid (CF3COOH) ne 2,2,2-trifluoroethanol (CF3CH2OH) pasi pemamiriro e acidic. Kuita uku kunogadzira TFETA pamwe chete nemvura sechinhu chimwe, chinogona kucheneswa kuburikidza ne distillation kana solvent extraction kuti iwane kuchena kwakanyanya kwakakodzera kushandiswa mumaindasitiri. Kugadzirwa kwakajeka uye kubata kweTFETA kunobatsira mukushanda kwayo kwemari uye kushandiswa kwakapararira muzvikamu zvakasiyana-siyana zvinoda fluorinated compounds. Muchidimbu, 2,2,2-trifluoroethyl trifluoroacetate chinhu chinoshandiswa zvakasiyana-siyana chakakosha mukugadzirwa kwezvinhu zvakasikwa, sainzi yezvinhu, uye kemikari yemishonga. Hunhu hwayo hwemakemikari hwakasiyana hunogonesa kugadzirwa kwezvinhu zvepamusoro nemishonga zvine kugadzikana kwakawedzerwa uye hunhu hwekushanda, zvichisimbisa kukosha kwayo mumashandisirwo emazuva ano emaindasitiri.