(2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid CAS:132622-78-7

Kubatsira kwakawanda kwe (2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid kuri mukushandiswa kwayo kwakasiyana-siyana mukutsvagisa kwemishonga, kemesitiri yemishonga, uye kuwanikwa kwemishonga. Sechivakwa che chiral, yakakosha pakugadzirwa kwemamorekuru matsva e organic uye mishonga inogona kushandiswa. Vaongorori vanoshandisa chimiro chayo chekuvaka kuti vaongorore basa rayo mukugadzira mishonga yekurapa inotarisa kuzvirwere zvakasiyana-siyana, zvichigona kutungamira mukugadzirwa kwezvigadzirwa zvitsva zvemishonga zvine simba rakawedzerwa uye hunyanzvi hwe pharmacokinetic hwakavandudzwa, zvichipa mabhenefiti anogona kuwanikwa muhutano nemishonga. Uyezve, iyi compound inoshandiswa mukugadzirwa kwepeptide uye makemikari ekubatanidza, ichibatsira mukugadzirwa kwemishonga yakasiyana-siyana ye peptidomimetics uye peptide-based. Hunhu hwayo hwe chiral hunoita kuti ive yakakosha pakugadzirwa kwepeptides chaiyo ine hunyanzvi hwakagadzirirwa, kuwedzera huwandu hwesarudzo dzekurapa dziripo mukugadzirwa kwemishonga. Pamusoro pezvo, (2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid inotsigira kutsvaga maitiro matsva emakemikari uye kuvandudzwa kwenzira itsva dzekugadzira, ichipa vaongorori nevanoongorora mishonga chishandiso chinoshanduka-shanduka chekugadzira maumbirwo matsva emamorekuru. Kushandiswa kwayo kwakawanda kunosimbisa basa rayo guru mukufambisa hunyanzvi nekufambira mberi mukati mekugadzirwa kwezvinhu zvakasikwa, kutsvagisa mishonga, uye indasitiri yakakura yemakemikari, ichipa nzira dzakanaka dzekuvandudza zvigadzirwa zvitsva nematekinoroji. Kazhinji, mashandisirwo akasiyana-siyana ekomponi iyi anoiisa sechinhu chakakosha mukutsvagisa kwesainzi uye kutsvaga mabasa emaindasitiri.