Abiraterone CAS:154229-19-3

Abiraterone inonyanya kushandiswa mukurapa kenza yeprostate inodzivirira metastatic castration (mCRPC). Semushonga une simba we androgen biosynthesis, inonanga enzyme CYP17A1, yakakosha mukugadzirwa kwe testosterone nedzimwe androgens. Nekuvharira iyi enzyme, abiraterone inodzikisa kugadzirwa kwe androgen muma testes nemubundu pacharo, nokudaro ichideredza huwandu hwe androgens dzinokurudzira kukura kwekenza yeprostate. Mukurapa, abiraterone inopihwa nemuromo pamwe chete ne prednisone kana prednisolone kuderedza migumisiro inogona kuitika. Iyi nzira yekurapa yakaratidza kushanda kwakakosha mukuvandudza huwandu hwekurarama uye kunonoka kufambira mberi kwechirwere muvarwere vane kenza yeprostate yepamusoro vakambogamuchira androgen deprivation therapy (ADT). Uyezve, mhedzisiro yekurapa yeabiraterone inopfuura mCRPC. Tsvagiridzo iri kuenderera mberi inoongorora kugona kwayo mumatanho ekutanga ekenza yeprostate uye pamwe chete nedzimwe nzira dzekurapa dzakadai se chemotherapy uye nzira itsva dzekurapa. Maitiro ayo ekushanda uye mabhenefiti ekiriniki zvinoramba zvichiongororwa mumiedzo yakasiyana-siyana yekiriniki kuti zvivandudze mhedzisiro yekurapa uye kutarisirwa kwevarwere. Muchidimbu, abiraterone ibasa guru mukurapa kenza, kunyanya mukurapa kenza yeprostate. Kugona kwayo kukanganisa kugadzirwa kwe androgen kunopa nzira yakanangana yekurapa bundu rinokonzerwa nemahormone, zvichipa varwere kurarama kwenguva refu uye hupenyu huri nani. Kufambira mberi kuripo uye zvidzidzo zvekiriniki zvinosimbisa basa rayo guru mukuvandudza nzira dzekurapa kenza, zvichivimbisa nzira itsva dzekutarisira kenza yemunhu oga.