Acetylcholinesterase CAS:9000-81-1

Mishonga inorwisa mabhakitiriya imhando yemishonga kana makemikari anodzivirira kushanda kweenzyme inonzi acetylcholinesterase. Acetylcholinesterase ndiyo inokonzeresa kupwanya neurotransmitter acetylcholine mumuviri. Nekudzivisa iyi enzyme, mishonga inorwisa mabhakitiriya inowedzera huwandu hweacetylcholine, zvichikonzera kuwedzera kwecholinergic activity mutsinga dzepakati nepamativi.

Kushandiswa kukuru kwemishonga yekudzivirira chirwere chepfungwa (anticholinesterases) mukurapa zvirwere zvetsinga zvakaita sechirwere cheAlzheimer ne myasthenia gravis. Muchirwere cheAlzheimer, mishonga iyi inovavarira kuwedzera cholinergic neurotransmission uye inogona kuderedza kudzikira kwepfungwa. Mu myasthenia gravis, mishonga yekudzivirira chirwere chemoyo inobatsira kuvandudza kufambiswa kwetsinga dzemuviri uye simba retsandanyama.

Mamwe mashandisirwo emishonga inorwisa cholinesterases anosanganisira kuongororwa nekurapa chepfu yecholinergic, kunyanya kubva kune mimwe mishonga inouraya zvipembenene kana tsinga. Zvinhu izvi zvinogona kukonzera kukurudzirwa kwakanyanya kwemuscarinic ne nicotinic receptors, zvichikonzera zviratidzo zvakaita sekushaya simba kwetsandanyama, kudedera, uye kufema. Mishonga inorwisa cholinesterases inogona kuchinja mhedzisiro iyi nekuwedzera huwandu hweacetylcholine uye kukwikwidzana nezvinhu zvine chepfu.

Odha kana Kumbira Mutengo

Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Kushandiswa uye Mhedzisiro

Mugumisiro weanticholinesterase unoreva kugona kwemamwe mishonga kana makemikari kudzivirira kushanda kweenzyme inonzi acetylcholinesterase. Acetylcholinesterase ndiyo inokonzera kupwanya neurotransmitter acetylcholine mumuviri. Nekudzivisa iyi enzyme, anticholinesterases inowedzera huwandu hweacetylcholine, zvichikonzera kuwedzera kwecholinergic activity.

Kushandiswa kukuru kwemishonga yekudzivirira chirwere checholinesterases ndekurapa zvirwere zvinoonekwa nekudzikira kwemabasa ekudzivirira chirwere checholinergic. Izvi zvinosanganisira zvirwere zvetsinga zvakaita sechirwere cheAlzheimer's uye myasthenia gravis. Muchirwere cheAlzheimer's, mishonga yekudzivirira chirwere checholinesterase yakaita sedonepezil, rivastigmine, uye galantamine inoshandiswa kudzivirira kuparara kweacetylcholine uye kuwedzera cholinergic neurotransmission. Izvi zvinogona kubatsira kuvandudza mashandiro epfungwa uye zvingangoderedza kufambira mberi kwechirwere.

Mukurapa kwemyasthenia gravis, mishonga inorwisa cholinesterase yakaita seyeostigmine nepyridostigmine inoshandiswa kuwedzera kutapurirana kwetsinga dzemutsinga. Mishonga iyi inodzivirira acetylcholinesterase uye inowedzera huwandu hweacetylcholine panzvimbo inoungana tsandanyama dzemutsinga, zvichivandudza simba retsandanyama uye kuderedza kushaya simba kwetsandanyama.

Mishonga yeAnticholinesterases inewo mashandisirwo ekuongorora uye ekurapa muzviitiko zvechepfu yeAnticholinergic. Mishonga yeAnticholinergic, yakadai semimwe mishonga yekuuraya zvipembenene kana mishonga yetsinga, inogona kukonzera kuvharika kwakanyanya kwecholinergic zvichikonzera zviratidzo zvakaita sekuvhiringidzika, kurova kwemoyo nekukurumidza, muromo wakaoma, uye kuona zvisipo. Muzviitiko zvakadaro, mishonga yeAnticholinesterases yakaita sePralidoxime inogona kushandiswa kuderedza mhedzisiro nekuwedzera huwandu hweacetylcholine uye kukwikwidzana nezvinhu zvine chepfu.

Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	NA
Kuyedza	99%
Chitarisiko	Upfu hweyero yakapfava
Nhamba yeCAS	9000-81-1
Kurongedza	Diki uye rakakura
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.