Ethionamide CAS:536-33-4

Ethionamide chinhu chakakosha mukurapa chirwere cheTB chisingadi mishonga yakawanda (MDR-TB) uye chirwere cheTB chisingadi mishonga yakawanda (XDR-TB), mhando mbiri dzeTB dzisingadi mishonga yekutanga. Mushonga uyu unowanzo shandiswa sechikamu chekurapa kwakazara kunosanganisira mishonga yakawanda yekurwisa hutachiona hweTB hunokonzerwa nemarudzi asingadi mishonga. Ethionamide inoshanda nekuvhiringidza kugadzirwa kwemycolic acids mukati memadziro emasero ebhakitiriya eMycobacterium tuberculosis, nokudaro ichidzivisa kukura kwebhakitiriya uye kuberekana kwaro. Zvakakosha kutevedzera dosage yakatarwa uye kupedzisa kurapwa kwakazara kuti uwane mhedzisiro yakanaka yekurapa uye kudzivirira kukura kwekusada mishonga zvakare. Migumisiro yakajairika ye ethionamide inogona kusanganisira matambudziko emudumbu akadai sekuda kurutsa, kurutsa, uye kurwadziwa mudumbu, pamwe nezviratidzo zvetsinga zvakaita seperipheral neuropathy. Kuongororwa nguva dzose nevanopa hutano kwakakosha kuti vaongorore kushanda kwekurapa uye kugadzirisa chero maitiro asina kunaka nekukurumidza. Varwere vanofanira kutevedzera zvakanyanya maitiro avo ekurapa uye kugadzwa kwekutevera kuti vatarise kufambira mberi uye kuona kuti kupora kunobudirira kubva kuhutachiona hweTB. Ethionamide ine basa rakakosha mukurwisa chirwere cherurindi chisingarapike nemishonga uye inosimbisa kukosha kwekushandisa mishonga yakawanda mukugadzirisa dambudziko repasi rose rechirwere ichi chinotapukira.