Fidaxomicin CAS:873857-62-6

Fidaxomicin inonyanya kuitirwa kurapa hutachiona hweClostridioides difficile, kunyanya kana paine CDI iri pakati nepakati kusvika yakanyanya apo mishonga yechivanhu yaisashanda zvakanaka kana kuti ine chekuita nekudzoka kwakawanda kwechirwere. Inopihwa nemuromo muchimiro chepiritsi, zvichibvumira kuendeswa kwakanangana kunzvimbo yehutachiona muura. Maitiro akasiyana ekushanda kwefidaxomicin anosanganisira kudzivirira RNA polymerase yebhakitiriya, zvichikanganisa kugadzirwa kweprotein mumasero eC. difficile. Nekutarisa pathogen iyi isina kukanganisa microbiota inobatsira mudumbu, fidaxomicin inobatsira kudzorera kuenzana kwehutachiona muura uye kuderedza njodzi yekudzoka kweCDI. Varwere vane hutachiona hweC. difficile hwakasimbiswa kana hunofungidzirwa vanowanzo pihwa fidaxomicin kwenguva yakatarwa zvichienderana nekuoma kwehutachiona. Kutevedzera dosi yakatarwa uye regimen kwakakosha kuti uwane mhedzisiro yakanaka yekiriniki uye kuderedza njodzi yekudzoka. Migumisiro yakajairika inogona kusanganisira kuda kurutsa, kurwadziwa mudumbu, uye kusagadzikana kwemudumbu; zvisinei, fidaxomicin inowanzo ratidza kushivirira kwakanaka kana ichienzaniswa nedzimwe nzira dzekurapa dzeCDI. Kugara uchitarisa panguva yekurapwa uye kuongororwa mushure mekurapwa kwakakosha kuti uongorore mhinduro, utarise kana paine matambudziko, uye udzivise kudzokerazve kwehutachiona hweC. difficile. Vanopa hutano vanoita basa rakakosha mukutungamira kushandiswa kwakakodzera kwefidaxomicin kuti vatarisire CDI zvinobudirira uye kukurudzira kupora kwemurwere.