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Adenosine CAS:58-61-7
Adenosine inyuchi inoumbwa neadenine ne ribose, ichitamba basa guru mukugadzirwa kwemasero. Inoshanda sechivako chikuru che adenosine triphosphate (ATP), iyo inonyanya kukosha muzvinhu zvipenyu. Kunze kwemabasa ayo ane chekuita nesimba, adenosine inobatanidzwa mumabasa akasiyana-siyana emuviri, anosanganisira kutumirwa kwetsinga, kuyerera kweropa, uye kudzora kutenderera kwekurara nekumuka. Inoshanda pama receptors chaiwo, ichipesvedzera kurova kwemoyo uye kuyerera kweropa. Mukurapa, adenosine inoshandiswa mukurapa, kunyanya mukurapa mamwe ma arrhythmia emwoyo. Mabasa ayo akawanda anoratidza kukosha kwe adenosine muhutano nezvirwere.
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Uridine 5-monophosphate, disodium munyu CAS:3387-36-8
Uridine 5-monophosphate, disodium salt (UMP) inyukleotide ine basa rakakosha mukugadzirwa kwemasero uye kugadzirwa kweRNA. Iine pyrimidine base uracil, ribose sugar, uye boka rephosphate, UMP inokosha pakuita zvakasiyana-siyana kwehupenyu, kusanganisira kuumbwa kwe nucleic acids uye kudzora nzira dze metabolic. Munyu we disodium unowedzera kunyungudika kwayo uye kugadzikana kwayo mumvura, zvichiita kuti ive yakakodzera kutsvagurudza murabhoritari uye kushandiswa kwekurapa. UMP yakwezva kutariswa nekuda kwesimba rayo rekudzivirira tsinga uye kusimudzira kugona, pamwe nebasa rayo mukusimudzira hutano hwese hwemasero.
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Cytidine 5′- (disodium phosphate) CAS:6757-06-8
Cytidine 5′- (disodium phosphate) chinhu chinobva mu nucleotide chinoumbwa ne pyrimidine base cytosine, ribose sugar, uye phosphate group. Iyi compound inoita basa rakakosha mumaitiro akasiyana-siyana e biochemical, kusanganisira RNA synthesis, regulatory pathways, uye cellular signaling. Munyu we disodium unowedzera kunyungudika kwayo uye kugadzikana mumamiriro emuviri, zvichiita kuti ikodzere kutsvagurudza murabhoritari uye kushandiswa kwekurapa. Cytidine 5′- (disodium phosphate) yakawana kufarira kwekubatanidzwa kwayo mu nucleic acid metabolism uye mabhenefiti ayo anogona kuwanikwa mukusimudzira mashandiro epfungwa nekutsigira hutano hwemasero.
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5-Azacytidine CAS:320-67-2
5-Azacytidine imhando ye cytidine inonzi cytidine ine atomu renitrogen iri panzvimbo ye pyrimidine ring, ichitsiva atomu recarbon. Kuchinja uku kunoita kuti ive chinhu chakakosha mu molecular biology uye cancer therapy. Semushonga une simba weDNA methyltransferase inhibitor, 5-azacytidine inogona kudzorera majini akavharirwa nekuchinja DNA methylation patterns, nokudaro ichikanganisa magene expression. Pakutanga yakagadzirwa kurapa marariya eropa, 5-azacytidine yave kuzivikanwa nekuda kwekushandiswa kwayo mu epigenetic therapy, regenerative medicine, uye research inotarisa zvirwere zvakasiyana-siyana zvinoratidzwa ne abnormal gene regulation.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) imhando ye deoxyuridine inofanana ne nucleoside, uko atomu rehydrogen riri panzvimbo ye ribose shuga rinotsiviwa neatomu re fluorine. Kuchinja uku kunosimudzira kugadzikana uye kushanda kwechinhu ichi, zvichiita kuti chive chakakosha mukutsvagisa kwe biochemical uye kushandiswa kwekurapa. FdU inozivikanwa zvikuru nebasa rayo semushonga wekurwisa kenza uye antiviral, sezvo ichigona kukanganisa kugadzirwa kweDNA uye kudzivirira kudzokororwa kwemamwe mavhairasi nemasero ekenza. Hunhu hwayo hwakasiyana hunoita kuti ive chishandiso chakakosha mukuvandudza mishonga yakanangwa uye zvidzidzo zve molecular biology.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one imhando ye nucleoside analog ine pyrimidine base yakabatana ne modified ribose sugar. Kuvapo kwe fluorine atomu ne hydroxyl groups muchimiro chayo kunowedzera hunhu hwayo hwe biochemical, zvichiita kuti ive mukana unonakidza wekutsvaga ma virus ne cancer. Iyi compound inogona kushandiswa mu medical chemistry, kunyanya se therapeutic agent inotarisa nucleic acid synthesis uye metabolic pathways mu pathogenic organisms. Hunhu hwayo hwakasiyana hwechimiro hunoita kuti pave nekudyidzana kuri nani ne biological target dzinobatanidzwa mu DNA ne RNA metabolism.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose imhando ye ribose yakagadziriswa nemakemikari, ine mapoka matatu ebenzoyloxy akabatana nenzvimbo dze1, 3, uye 5 dzechimiro che ribofuranose. Kugadziriswa uku kunowedzera kunyungudika kwayo uye kugadzikana, zvichiita kuti ishande mukushandiswa kwakasiyana-siyana kwekugadzira mu organic chemistry uye biochemistry. Sechinhu chakachengetedzwa kubva ku ribose, inoshanda sepakati mukugadzirwa kwe nucleosides ne nucleotides, zvikamu zvakakosha zveRNA neDNA. Hunhu hwayo hwakasiyana hunoita kuti 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose ive yakakosha kune vaongorori vari kutsvaga kugadzira mishonga mitsva uye zvinhu mu nucleotide chemistry.
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2′-O-methyluridine CAS:2140-76-3
2′-O-Methyluridine inyuchi inongoitika yoga umo boka remethyl rinonamirwa kuatomu yeokisijeni yenzvimbo ye2′ yeshuga yeribose muuridine. Kuchinja uku kunosimbisa kugadzikana uye kushanda kwemamorekuru eRNA, zvichiita kuti ive chinhu chakakosha mumaitiro akasiyana-siyana ehupenyu. 2′-O-Methyluridine inoita basa rakakosha muchimiro uye basa reribonucleic acids (RNAs), kusanganisira messenger RNA (mRNA) uye transfer RNA (tRNA). Kuvapo kwayo kunogona kukanganisa kugadzikana kweRNA, kushanda zvakanaka kwekushandura, uye kudyidzana nemapuroteni nedzimwe nucleic acids, zvichiita kuti ive chinhu chakakosha mukudzidza kwemolecular biology uye mashandisirwo ekurapa.
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adenosine 5′-monophosphate sodium*kubva kumbiriso CAS:4578-31-8
Adenosine 5′-monophosphate sodium (AMP) inyukleotide inobva kuadenosine inoita basa rakakosha mukushandiswa kwemasero. AMP inokosha pamabasa akasiyana-siyana ehupenyu, kusanganisira kutamiswa kwesimba, kufambiswa kwemashoko, uye senzira yekutanga kugadzirwa kweATP nedzimwe nukleotide. Munyu wesodium weAMP unogona kubva kumbiriso, iyo ine nukleotide yakawanda nekuda kwenzira dzayo dzekushanda. Musanganiswa uyu unowanzoshandiswa mu biochemistry uye pharmacology se reagent yebiochemical, chinowedzera chikafu, uye chinowedzera kudya, nekuda kwekubatsira kwayo pahutano uye mashandisirwo ayo mukusimudzira kushandiswa kwesimba.
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2′-Deoxycytidine CAS:951-77-9
2′-Deoxycytidine inyuchi inoumbwa neshuga ye deoxyribose ne cytosine, inosiyaniswa nekushaikwa kweboka re hydroxyl panzvimbo ye 2′ ye ribose. Kugadziriswa uku kunoita kuti ive chinhu chakakosha cheDNA, uko inobatana ne guanine panguva yekubatanidza base. 2′-Deoxycytidine inoita basa rakakosha mu metabolism yemasero uye kugadzirwa kweDNA, inoshanda sechivako che deoxycytidine triphosphate (dCTP), iyo inokosha pakudzokororwa kweDNA nekugadzirisa. Pamusoro pezvo, iyi nucleoside ine zvakakosha mukutsvagisa kwe molecular biology, kurapwa nekenza, uye nzira dzekudzivirira utachiona, zvichiratidza kukosha kwayo mukutsvagisa kwakakosha uye kushandiswa kwekiriniki.
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2,2′-cyclouridine CAS:3736-77-4
2,2′-Cyclouridine chinhu chinobuda muuridine chinonzi bicyclic nucleoside, chinoratidzwa nekuumbwa kwechimiro chakasiyana checyclic chinosanganisira nzvimbo dze2′ ne2” dze ribose moiety. Kugadziriswa kwechimiro ichi kunoita kuti pave nehunhu hwakasiyana hwebiochemical hunokanganisa kugadzikana kwayo uye mashandiro ayo ehupenyu. 2,2′-Cyclouridine yakawana kufarira mu biology yemakemikari uye chemistry yekurapa nekuda kwekushandiswa kwayo semushonga wekudzivirira utachiona uye mukutsvagisa kweRNA. Kugona kwayo kugadzirisa kusangana kwe nucleic acid kunoita kuti ive chishandiso chakakosha chekudzidza hukama hweRNA structure-function, zvichigona kutungamira mukufambira mberi mukurapa kunonangana nehutachiona hwehutachiona nezvirwere zvemajini.
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2-Aminoadenosine CAS:2096-10-8
2-Aminoadenosine chinhu chinobva mu nucleoside derivative ye adenosine, chinosiyaniswa nekuvapo kweboka reamino panzvimbo ye ribose shuga. Kuchinja uku kunochinja zvakanyanya hunhu hwayo hwe biochemical uye mashandiro ayo, zvichiita kuti ive molekyuru inokosha mumabasa akasiyana-siyana emuviri. 2-Aminoadenosine inobatanidzwa mukutumira zviratidzo mumasero, metabolism, uye nzira dzekutonga, kusanganisira dzine chekuita ne energy homeostasis uye neurotransmission. Mashandisirwo ayo ekurapa anogona kusanganisira minda yakawanda, kusanganisira neurobiology ne cardiology, uko inogona kukanganisa mhinduro dzemasero kushushikana nekukuvara. Sezvo tsvakiridzo ichienderera mberi, 2-aminoadenosine ine vimbiso yekugadzira mishonga mitsva ye bioactive uye mishonga yekurapa.
