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Pristinamycin CAS:270076-60-3
Pristinamycin mushonga unosanganisa maantibiotic une zvinhu zviviri zvinoshanda, pristinamycin I napristinamycin II. Iri muboka remaantibiotic estreptogramin uye ine mabasa ekuuraya utachiona uye ekuuraya utachiona pakurwisa mabhakitiriya akasiyana-siyana ane gram-positive, anosanganisira Staphylococcus aureus naStreptococcus pneumoniae. Pristinamycin inoshanda nekudzivisa kugadzirwa kwemapuroteni emabhakitiriya, zvichiita kuti ishande mukurapa hutachiona hweganda nenyama yakapfava, hutachiona hwekufema, uye humwe hutachiona hunokonzerwa nehutachiona hunogona kupararira.
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Ribostamycin sulfate CAS:53797-35-6
Ribostamycin sulfate mushonga unorwisa mabhakitiriya unobva kuStreptomyces griseoluteus. Une simba guru rekuuraya mabhakitiriya kubva kubhakitiriya ane gram-negative nemamwe gram-positive nekudzivisa kugadzirwa kwemapuroteni. Ribostamycin sulfate inowanzoshandiswa mukurapa hutachiona hwakasiyana-siyana, kusanganisira hutachiona hwemunzira yeweti, hutachiona hwekufema, hutachiona hweganda nenyama yakapfava, uye septicemia inokonzerwa nemabhakitiriya anopararira.
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Rifampicin CAS:13292-46-1
Rifampicin, inozivikanwawo serifampin, mushonga unorwisa mabhakitiriya une mativi akasiyana-siyana uri muboka rerifamycin. Unoshandiswa zvakanyanya mukurapa TB, maperembudzi, nezvimwe zvirwere zvebhakitiriya. Rifampicin inoshanda nekudzivisa kugadzirwa kweRNA mumabhakitiriya, nokudaro ichikanganisa kugona kwawo kuberekana nekurarama. Nekuda kwekushanda kwayo nesimba kwemishonga inorwisa mabhakitiriya uye kushanda kwayo pakurwisa mycobacterial species, rifampicin chinhu chakakosha mumishonga inosanganiswa yekurapa TB nezvimwe zvirwere zvinotapukira.
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Puromycin dihydrochloride CAS:58-58-2
Puromycin dihydrochloride mushonga une simba wekuuraya mabhakitiriya uye mapuroteni unodzivirira kubva kuStreptomyces alboniger. Unoshandiswa zvakanyanya mukutsvagisa kwemakemikari emuviri kudzivirira kugadzirwa kwemapuroteni mumasero nekugumisa kushandurwa nguva isati yakwana panguva yekugadzira mapuroteni. Puromycin dihydrochloride inosanganiswa mumaketani epeptide ari kubuda, zvichikonzera kuburitswa kwemapolypeptide asina kukwana uye pakupedzisira kufa kwemasero. Nekuda kwekushanda kwayo kwakasiyana, puromycin dihydrochloride chishandiso chakakosha chekudzidza kugadzirwa kwemapuroteni, basa re ribosome, kuratidzwa kwemajini, uye kugara kwemasero munzvimbo dzekuedza.
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Protionamide CAS:14222-60-7
Protionamide mushonga unorwisa mabhakitiriya uri muboka rethioamide, unonyanya kushandiswa pakurapa TB isingapindi mishonga yakawanda. Unoshanda nekudzivisa kugadzirwa kwe mycolic acid mumadziro emasero ebhakitiriya, zvichikonzera kuparadzwa kweMycobacterium tuberculosis. Protionamide inowanzo kunyorerwa pamwe chete nemimwe mishonga yekurwisa TB sechikamu chekurapa kwakazara kwemhando dzeTB isingapindi mishonga.
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Potassium clavulanate CAS:61177-45-5
Potassium clavulanate inhibitor yeβ-lactamase inowanzo sanganiswa nemamwe maantibiotics kuti iwedzere kushanda kwayo pakurwisa hutachiona hwebhakitiriya. Inoshanda nekudzivirira kuparara kwemishonga inorwisa mabhakitiriya nema enzymes ebhakitiriya, nokudaro ichiwedzera kushanda kwayo uye inovandudza mhedzisiro yekurapa. Potassium clavulanate inowanzoshandiswa mumishonga inosanganiswa nemishonga inorwisa mabhakitiriya senge amoxicillin kurapa hutachiona hwakasiyana-siyana hwebhakitiriya.
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Retapamulin CAS:224452-66-8
Retakamulin mushonga unorwisa mabhakitiriya uri muboka remishonga inonzi pleuromutilin. Unoshandiswa kurapa hutachiona hweganda hwebhakitiriya, kunyanya impetigo inokonzerwa nemarudzi eStaphylococcus aureus neStreptococcus pyogenes. Retakamulin inoshanda nekudzivisa kugadzirwa kwemapuroteni ebhakitiriya, zvichikonzera kubviswa kwehutachiona hwehutachiona uye kupera kwehutachiona hweganda.
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Staurosporine, streptomyces staurosporeus CAS:62996-74-1
Staurosporine chigadzirwa chechisikigo chakaparadzaniswa nebhakitiriya reStreptomyces staurosporeus. Chinoiswa muboka realkaloid ine simba ine basa guru rezvehupenyu, kunyanya mukudzivisa mapuroteni kinases uye kukonzera apoptosis yemasero. Staurosporine yakaongororwa zvakanyanya nekuda kwehunhu hwayo hwemishonga, kusanganisira kugona kwayo kurwisa kenza uye basa rayo sechishandiso chekutsvagisa muzvidzidzo zvemasero.
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Phosphomycin disodium munyu CAS:26016-99-9
Munyu wePhosphomycin disodium mushonga unorwisa utachiona unoshandiswa mukurapa hutachiona hwakasiyana-siyana. Uri muboka re phosphonic acids uye unoshanda nekudzivisa kugadzirwa kwemadziro emasero ebhakitiriya. Upfu uchena uyu unonyungudika mumvura zvakanyanya uye unowanzopihwa nemukati kana nemuromo. Munyu wePhosphomycin disodium unozivikanwa nekushanda kwawo kurwisa mabhakitiriya akasiyana-siyana ane gram-positive ne gram-negative, zvichiita kuti uve sarudzo inoshanda pakurapa hutachiona.
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Phleomycin CAS:11006-33-0
Phleomycin mushonga unorwisa mabhakitiriya une simba unoshandiswa mukutsvagisa kwemakemikari emuviri pakusarudza masero ane jini rinonakidza. Nekushandisa nzira yekushanda inosanganisira kupatsanurwa kweDNA, Phleomycin inoshanda kurwisa mabhakitiriya akasiyana-siyana uye yave ichishandiswa zvakanyanya mumabasa akasiyana-siyana ekutsvagisa. Mushonga uyu unowanzo shandiswa pamwe chete nezvimwe zviratidzo zvekusarudza kugadzira masero akagadzikana ane shanduko dzemajini dzinodiwa. Phleomycin inowanikwa mumhando dzemvura nedzehupfu, zvichiita kuti ive nyore kushandisa uye ive nyore kune dzakasiyana siyana dzekuyedza. Vatsvagiri vanokoshesa kushanda kwayo kwakanyanya uye kuvimbika mukusarudza masero akachinjwa, zvichiita kuti ive chishandiso chakakosha muzvidzidzo zveinjiniya yemajini.
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Penicillin V potassium salt CAS:132-98-9
Munyu wePotassium wePenicillin V mushonga unorwisa utachiona unonwiwa nemuromo unorapa hutachiona hwebhakitiriya. Une penicillin V, munyu wePotassium wePhenoxymethylpenicillin. Penicillin V inoshanda nekuvhiringidza kugadzirwa kwepeptidoglycan mumadziro emasero ebhakitiriya. Izvi zvinoderedza simba remadziro emasero uye zvinouraya kana kudzivirira kukura kwebhakitiriya inobatwa nechirwere. Inowanikwa semapiritsi kana mishonga inonwiwa nemuromo kuti irapwe nehutachiona hushoma kusvika pakati nepakati.
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Penicillin G sodium salt (Benzylpenicillin sodium salt) CAS:69-57-8
Penicillin G sodium salt mushonga unorwisa mabhakitiriya une penicillin G muchimiro chayo chesodium salt. Unoshanda nekudzivisa kugadzirwa kwepeptidoglycan layers mumadziro emasero ebhakitiriya, zvichiuraya mabhakitiriya anonyanya kubatwa nechirwere. Penicillin G sodium salt inowanikwa semakristaro machena kana anenge machena kana upfu hunofanira kugadziriswazve kuita mushonga usati wabayiwa. Unopa penicillin G inotumirwa mumuviri kuti irape hutachiona hwebhakitiriya.
