Fmoc-Cys(Asi)-OH CAS:67436-13-9

Fmoc-Cys(But)-OH inoshanda sechishandiso chakakosha mukugadzirwa kwepeptide, kunyanya mukugadzira mapeptide ane cysteine ​​nemazvo. Boka rinodzivirira Fmoc rinodzivirira boka reamino, richivimbisa maitiro akasarudzwa panguva yekubatanidza peptide, nepo boka rebutyl richiwedzera imwe layer yekudzivirira kuboka rethiol. Vaongorori vanoshandisa zvakanyanya Fmoc-Cys(But)-OH mukugadzira mapeptide ekushandisa akasiyana-siyana, kusanganisira kugadzira mishonga inobva kupeptide, bioconjugation, uye kugadzira mapeptide ane maficha chaiwo ekuvaka. Kuenderana kwayo nemaitiro akajairwa ekugadzira peptide, mune ese ari maviri solid-phase uye solution-phase strategies, kunowedzera kushanduka kwayo mumabasa akasiyana-siyana ekutsvagisa. Kubviswa kwakadzorwa kwemapoka anodzivirira kunobvumira kuiswa kwecysteine ​​​​muzvikamu zvepeptide, kuwedzera huwandu hwemapeptide anogona kugadzirwa. Uyezve, Fmoc-Cys(But)-OH inowana rubatsiro mukudzidza kwekupeta mapuroteni, kuumbwa kwe disulfide bond, uye kugadzirwa kwezvinhu zvinobva kupeptide. Kushandiswa kweboka rekudzivirira butyl kunogonesa kushandiswa kwakanyatsojeka kwe cysteine ​​reactivity, zvichipa vaongorori chishandiso chakakosha chekugadzira ma peptide ane shanduko dzakagadzirirwa ivo. Mukupfupisa, Fmoc-Cys(But)-OH inomira sechishandiso chinoshandiswa zvakasiyana-siyana uye chisingakoshi mu peptide chemistry, ichipa vaongorori simba rekuongorora nekugadzirisa cysteine ​​reactivity kune akasiyana mashandisirwo esainzi, kunyanya kutarisa ma peptide ane iyi amino acid inokosha.