Geldanamycin CAS:30562-34-6

Geldanamycin mushonga unorwisa mabhakitiriya unobva kuStreptomyces hygroscopicus. Uri muboka rebenzoquinone ansamycins uye unoratidza simba guru rekurwisa kenza nekudzivirira kupisa shock protein 90 (Hsp90), puroteni yechaperone inokosha pakurarama kwemasero ekenza. Geldanamycin yakaratidza tarisiro muzvidzidzo zvepamberi pekiriniki semushonga unogona kurapa mhando dzakasiyana dzekenza.

Odha kana Kumbira Mutengo

Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Kushandiswa uye Mhedzisiro:

Kunyangwe geldanamycin yakaratidza kushanda kwekurwisa kenza muzvidzidzo zverabhoritari, kushandiswa kwayo mukiriniki kwakaganhurirwa nekuda kwezvinetso zvine chekuita nehupfu uye kugadzikana. Kuedza kutsvagisa kuri kuenderera mberi kugadzira mishonga inotorwa kubva mu geldanamycin ine hunhu hwakavandudzwa hwe pharmacokinetic uye mhedzisiro yakaderera yekushandiswa kwekurapa. Munzvimbo dzekuedza, geldanamycin nemidziyo yayo yakaongororwa kugona kwayo kudzivirira kushanda kweHsp90, zvichikonzera kuora kwemapuroteni evatengi anobatanidzwa mukukura kwemasero ekenza uye kurarama. Maitiro aya anoita kuti geldanamycin ive mukana wekurapa kenza zvakanangana, kunyanya mukenza dzinoenderana nenzira dzinodzorwa neHsp90. Miedzo yekiriniki inoongorora kushanda uye kuchengetedzeka kwemishonga inotorwa kubva mu geldanamycin muvarwere vekenza iri kuenderera mberi kuti iongorore kugona kwayo semishonga inorwisa kenza. Zvidzidzo izvi zvine chinangwa chekuongorora mabhenefiti ekurapa emushonga, nzira dzakanakisisa dzekurapa, huwandu hwekupindura, uye chero mhedzisiro yakaipa inobatanidzwa kuti ione kushanda kwayo mukiriniki mukurapa kwekenza. Kushanda pamwe chete pakati pevaongorori, makambani emishonga, masangano ekutonga, uye vanopa hutano kwakakosha kusimudzira kukura kwemishonga inotorwa kubva mu geldanamycin uye kuunza mishonga mitsva yekurwisa kenza kuvarwere vanoda. Kuenderera mberi nekuferefeta nezvemhando yemishonga uye mhedzisiro yekiriniki yezvigadzirwa zvegeldanamycin kune vimbiso yekuvandudza nzira dzekurapa kenza nemigumisiro mune ramangwana.

Muenzaniso weChigadzirwa:

Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	C29H40N2O9
Kuyedza	99%
Chitarisiko	upfu chena
Nhamba yeCAS	30562-34-6
Kurongedza	Diki uye rakakura
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.