Glucose-6-Phosphate Dehydrogenase CAS:9001-40-5

Glucose-6-phosphate dehydrogenase (G6PD) ienzyme inobatanidzwa munzira yekuchinja kweglucose. Inoita basa rakakosha mukugadzirwa kweNADPH, molekyuru inokosha kune akasiyana maitiro emasero, kusanganisira kudzivirira maantioxidant uye biosynthesis yemafuta acids necholesterol.

G6PD inosimudzira kushandurwa kweglucose-6-phosphate kuita 6-phosphogluconolactone, ukuwo ichideredza NADP+ kuita NADPH. Kuita uku kwakakosha pakuchengetedza huwandu hwakakwana hweNADPH mumasero, izvo zvinodiwa kuti masero agare zvakanaka uye dziviriro kubva mukukuvadzwa kwe oxidative.

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Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Kushandiswa uye Mhedzisiro

Kuchinja kwemasero: G6PD inobatanidzwa munzira yekuchinja kweglucose, kunyanya nzira yepentose phosphate. Inobatsira kushandurwa kweglucose-6-phosphate kuita 6-phosphogluconolactone, zvichigadzira NADPH mukuita kwayo. NADPH imorekuru inokosha kune akasiyana maitiro emasero, anosanganisira kudzivirira maantioxidant, biosynthesis yemafuta acids necholesterol, uye kuchengetedza masero e redox balance.

Kudzivirira Maantioxidant: NADPH inogadzirwa neG6PD yakakosha pakugadzirwa kweglutathione yakaderedzwa (GSH), molecule inokosha yeantioxidant. GSH inodzivirira masero kubva mukushushikana kwe oxidative nekubvisa ma free radicals uye reactive oxygen species (ROS). Kushaikwa kweG6PD kunogona kukanganisa kuwanikwa kweNADPH uye kuderedza kushanda kwekudzivirira maantioxidant, zvichikonzera kuwedzera kwenjodzi yekukuvadzwa kwe oxidative.

Hemolytic Anemia: Kushaikwa kweG6PD ndiko kushomeka kwema enzyme kunowanzoitika pasi rose. Kunonyanya kukanganisa varume uye kunogona kukonzera hemolytic anemia, chirwere chinoratidzwa nekuparadzwa kwemasero matsvuku eropa. Zvimwe zvinokonzera, zvakaita sehutachiona, mimwe mishonga (semuenzaniso, mishonga yekurwisa malaria, mishonga yesulfa), uye zvimwe zvekudya (semuenzaniso, fava beans), zvinogona kukonzera hemolysis muvanhu vane G6PD kushomeka. Kushaikwa uku kunokonzera kutadza kudzora oxidative stress inokonzerwa neizvi zvinokonzera, zvichikonzera kuparara kwemasero matsvuku eropa.

Mishonga yeMishonga: Kuongororwa kweG6PD kwakakosha mukurapa mishonga yemishonga kudzivirira kusawirirana nemishonga. Mimwe mishonga, yakadai semamwe mishonga yekurwisa malaria (semuenzaniso, primaquine) uye mishonga inorwisa mabhakitiriya (semuenzaniso, sulfonamides), inogona kukonzera kubuda ropa muvanhu vane dambudziko reG6PD. Kuongororwa kweG6PD isati yasvika kunobatsira mukuziva vanhu vari panjodzi uye kunogona kutungamira kusarudzwa kwemishonga kana kushandiswa kwemamwe marapirwo kudzivirira matambudziko eropa.

Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	NA
Kuyedza	99%
Chitarisiko	Upfu chena
Nhamba yeCAS	9001-40-5
Kurongedza	Diki uye rakakura
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.