Mosapride CAS:112885-41-3

Mosapride, mushonga unosarudza we serotonin 5-HT4 receptor, unoshanda senzira inokosha yekurapa zvirwere zvakasiyana-siyana zvemudumbu zvinoratidzwa nekusashanda zvakanaka kwemuviri uye dyspepsia inoshanda. Basa rayo guru riri mukuvandudza kufamba kwemudumbu uye kubatana kwemuviri, kugadzirisa zviratidzo zvakaita sekuvharirwa kwenguva refu, dyspepsia isiri yemaronda, uye chirwere chegastroesophageal reflux (GERD). Pamusoro pezvo, mosapride inoratidza kushanda zvakanaka mukurapa ileus mushure mekuvhiyiwa uye gastroparesis yeshuga, zvichibatsira mukudzoreredza kubuda kwemudumbu kwakajairika uye kuderedza kusagadzikana kunoenderana nako. Mukurapa, mosapride inonyorerwa varwere vane zviratidzo zvemamiriro ezvinhu ane chekuita nedysmotility, kusanganisira kuzvimba, kuguta nekukurumidza, uye kuda kurutsa kunowanzoitika. Maitiro ayo anosanganisira kushandura kuburitswa kweacetylcholine mu enteric nervous system, izvo zvinotungamira mukuwedzera peristalsis uye kuvandudzwa kwekugara kwemudumbu. Basa iri remishonga rinoita kuti mosapride ibatsire zvakanyanya kune vanhu vane dyspepsia inoshanda, chirwere chinowanzoonekwa nekusagadzikana kwemudumbu uye kusagadzikana kwebasa remudumbu. Uyezve, mosapride inoita basa guru mukurapa gastroesophageal reflux, uko mhedzisiro yayo yeprokinetic inobatsira mukuderedza kusvibiswa kweasidhi yemudumbu uye kugadzirisa zviratidzo zvinoenderana nayo. Nekukurudzira kubuda kwemudumbu zvakanaka, inobatsira mukuderedza kudzoserwa kwezviri mudumbu mugumbo, nokudaro zvichivandudza hupenyu hwese hwevarwere vane chirwere ichi. Kazhinji, kushandiswa kwakasiyana-siyana kwemosapride mukiriniki kunoratidza kukosha kwayo semushonga unobatsira pakurapa zvirwere zvemudumbu. Kuburikidza nekuchinja kwayo nzira dze serotonergic uye kufambisa kubatana kwemudumbu, mosapride inopa rubatsiro runoshanda rwezviratidzo uye mhedzisiro inoshanda kune vanhu vari kurwisana nezvirwere zvakasiyana-siyana zvekugaya.