Acetyl Octapeptide-3 CAS: 868844-74-0 kuumbwa uye kushandiswa

Acetyl Octapeptide-3 (CAS 868844-74-0) ipeptide yakagadzirwa inozivikanwa zvikuru mune zvesainzi yezvekushongedza, inowanzo kutengeswa pasi pezita rekutengeserana rekuti SNAP-8. Ngationgororei zvakadzama maitiro ayo uye mashandisirwo ayo.

1. Kuzivikanwa uye Maitiro Ekuita

· Kuzivikanwa kweMakemikari:Ipeptide yakagadzirwa neacetylated ine sequence yeAc-Glu-Glu-Met-Gln-Arg-Arg-NH2. Acetylation inowedzera kupinda kwayo muganda uye kugadzikana.

· Maitiro Ekutanga:Inowanzonzi "imwe nzira yeBotox," mashandiro ayo anobva pakudziviswa kwemakwikwi. Inotevedzera N-terminal mugumo weSNAP-25 protein, chinhu chakakosha muSNARE complex chinodiwa pakuburitswa kwema neurotransmitters (senge acetylcholine) anoratidza kudzikira kwetsandanyama.

· Mhedzisiro Yakakosha:Nekukwikwidzana neSNAP-25 yechisikigo kuti ive panzvimbo yeSNARE complex, zvinodzivisa kuumbwa kwecomplex inoshanda zvizere. Izvi zvinoguma nekuderera kwechikamu chekusunungurwa kwe neurotransmitter, zvichikonzera kudzikira kwekusimba uye kuwanda kwekusungana kwemhasuru dzechiso, nokudaro zvichinyorovesa kutaridzika kwemitsetse yekutaura, kunyanya pahuma nepameso.

2. Nhungamiro dzeKugadzira

Acetyl Octapeptide-3 chinhu chine simba asi chinonaka. Kugadzirwa kwakakodzera kwakakosha kuti pave nekugadzikana uye kushanda zvakanaka.

A) Kukurudzirwa Kuisa Pfungwa Pamwe Chete:

· Danho rekushandisa rinowanzoitwa riri pakati pe2% kusvika 10%ye peptide solution yakasanganiswa kare.

· Hunhu hwepeptide inoshanda muzvinhu zvakabikwa (kazhinji hupfu huchena hwakasanganiswa) hunowanzo kuve hwakajairwa. Vatengesi vemabhizinesi vanowanzo hupa senzira yekudzivirira.2% kana 5%mushonga wakanyungudutswa kare (mumvura kana musanganiswa wemvura/glycerin) kuti zvive nyore kugadzira.

· Kuwanda kwepeptidi inoshanda muchikamu chekupedzisira kunowanzo bva0.0005% kusvika 0.002% (5-20 ppm)Gara uchitevera zvinokurudzirwa nemutengesi wezvinhu zvako.

B) Kunyungudika & Mota:

· Inonyungudika zvikuru mumvura. Inonyatsogadzirwa mumvura yechigadzirwa.

Mota dzakakodzera dzinosanganisira:

· MaSerum (anonyanya kuwanikwa)

· Majeli

· Makirimu neLotions (zvinofanira kuiswa mumvura usati waisa emulsification)

· Mafuta Anonhuwirira Anonaya Mvura

· Mhinduro Dzinopfapfaidzwa

C) pH uye Kugadzikana:

· Range yepH yakakwana:5.0 – 7.0Kugadzira mukati merudzi urwu kunoita kuti makemikari agare zvakanaka uye kuti ganda rienderane.

· Dzivisa nzvimbo dzine acid yakawanda (pH <4) kana alkaline (pH > 8) kwenguva yakareba.

D) Kupisa & Kugadzirisa:

· Inodziya zvakanyanya. Kudzivirira kuora kwechinhu:

· Wedzera mvura padanho remvura riri pasi kana kuti pasi paro40°C (104°F).

· Nzvimbo yakanaka yekuwedzera ndeye mushure mekunge emulsion yatonhorera kusvika pasi pe40°C, kana kungoinyungudutsa mumvura yekupisa kwemukamuri ye serums/gels.

· Dzivisa kugadziriswa kwekupisa kwakanyanya sekunge kuzadza kunopisa kunze kwekunge data rekugara richisimbisa izvozvo.

E) Kuenderana & Zvimisikidzo Zvinoenderana:

· Yakanaka kwazvo ine: Mamwe mapeptide anodzivirira kukwegura (semuenzaniso, Matrixyl, Argireline), hyaluronic acid, niacinamide, antioxidants (Vitamin C & E), moisturizers.

· Misanganiswa yekubatana:

· Nemamwe mapeptide ekugadzirisa neuromodulating: Anowanzo sanganiswa neAcetyl Hexapeptide-8 (Argireline) kuti pave nemhedzisiro yakakura uye inodzivisa zvinhu zvakawanda.

· Nemapeptide anosimudzira collagen: Kusanganiswa nemapeptide akaita sePalmitoyl Tripeptide-1 kana Matrixyl kunobata mitsetse inoshanduka (kubva mukufamba kwetsandanyama) uye mitsetse isingachinji (kubva mukurasikirwa nerutsigiro rwechimiro).

· Dzivisa: Zvinokonzera oxidation kana kuderedza simba. Chenjerera nemamwe ma ionic compounds anogona kukanganisa kunyungudika kwayo kana chimiro chayo.

F) Kuchengetedza:

· Sechinhu chinonyungudika mumvura, mushonga wekupedzisira unoda nzira yakasimba yekuchengetedza zvinhu zvakasiyana-siyana kudzivirira kukura kwehutachiona hunogona kukanganisa peptide.