Neocuproine reagent inoshandiswa pakutsvaga mhangura, chena kana yero-brown crystal, inonetsa. Inonyanya kushandiswa se reagent yekuona cuprous, photometric determination yemhangura, kuona ultra-micro blood sugar; organic synthesis. Neocuproine hydrochloride monohydrate yakashandiswa pakuyera kunyungudika kwemhangura muCu-Ni alloys uchishandisa nzira ye colorimetric. Yakashandiswawo mukugadzira complexing agent solution mukudzidza antioxidant capacity assays mu biological samples zvichibva paCu reducing complexes. Inogona kushandiswa se precursor yekugadzirira neocuproine, inoshandiswa se analytical reagent yekuona mhangura mu environment samples uchishandisa spectrophotometric technique.
Asi mushonga wakadaro une mashandisirwo akasiyana kwazvo mukurapa. Munguva pfupi yapfuura, Eribulin yakatenderwa kutengeswa neNational Medical Products Administration (NMPA) yenyika yangu yekurapa varwere vekenza yemazamu vanodzoka kana kuti vakapararira munharaunda yavo avo vakamborapwa kanenge kaviri (kusanganisira anthracyclines uye taxans) kare. Yakaunza nzira itsva yekurapa mumunda wechemotherapy yekenza yemazamu muChina, Inounzawo dzimwe nzira dzekurapa varwere.
Eribulin inodzivirira tubulin isiri taxane. Kusiyana netaxane nevinblastine tubulin inhibitors, Eribulin ine nzira yakakosha yekushanda, iyo inoita kuti Eribulin irambe ichishanda muvarwere mushure mekuramba mishonga; Eribulin inewo mhedzisiro isingakuvadzi, kusanganisira kugadzirisa tsinga dzeropa, kuwedzera kuyerera kwemamwe mishonga munzvimbo yebundu, kubatanidza mimwe mishonga, uye kudzosera kumashure masero ebundu The epidermal-mesenchymal transition nezvimwewo.
Kubva pakuumbwa kwehalichondrin B, kushandiswa kwezvishandiso zvitsva zvemhangura sezvinhu zvinopindirana, kusvika pakushandurwa kwechimiro cheEribulin, kusvika pakugadzirwa kweEribulin mumaindasitiri, masayendisiti kubva kumakambani edzidzo nemakambani emishonga vakapedza makore anopfuura makumi maviri vachiongorora. Zvigadzirwa zvechisikigo zvinobva mugungwa zvava mishonga inogona kurapa kenza. Kutsvagurudza nekugadzirwa kweEribulin imhaka yekuti chishandiso chitsva chemhangura chakakosha sechikamu chikuru cheAPI yayo. Chishandiso chitsva chemhangura chine basa guru sechikamu chinopindirana chemishonga uye chinoshandiswa pakuchenesa zvishandiso zvepamusoro.
Maumbirwo emamorekuru eEribulin ane nzvimbo gumi nepfumbamwe dzechiral, uye matanho ekugadzira akareba nhanho makumi matanhatu nembiri. Kusvika pari zvino, Eribulin ichiri kuonekwa neindasitiri semushonga wakaoma kwazvo usiri peptide unogadzirwa nekugadzirwa kwemakemikari akachena, uye unogona kunzi Mount Everest muindasitiri yekugadzira makemikari.
Kubudirira kwekunyorwa kweEribulin kunoratidza nhanho itsva dzinogona kusvikwa nemakambani emishonga mukugadzira mishonga yemakemikari uye kugadzirwa kwemaindasitiri. Izvi zvinounzawo mazano akawanda ekuongorora nekurapa uye sarudzo kune vanachiremba vekuChina. Zvinotarisirwa kuti mune ramangwana, mushonga mutsva wekurapa nemakemikari weEribulin unogona kuunza tariro itsva kune varwere vekenza yemazamu.
Nguva yekutumira: Ndira-01-2021