Nigericin CAS:28380-24-7

Nigericin yave ichishandiswa zvakanyanya mumarabhoritari ekutsvagisa kudzidza mashandiro ekutakura maion emasero, kudzora kugona kwemembrane, uye intracellular pH modulation. Hunhu hwayo hwe ionophoric hunoita kuti ive chishandiso chakakosha chekutsvaga nzira dze ion signaling, membrane permeability, uye cellular homeostasis. Vatsvaguri vanowanzo shandisa nigericin kudzora kuwanda kwemaion mumasero uye kuongorora mhedzisiro yayo pakushanda kwemasero uye kurarama. Kuwedzera kune mashandisirwo ayo ekutsvagisa, nigericin yakaratidza hunhu hwakanaka hwekurwisa kenza nekukurudzira apoptosis (kufa kwemasero kwakarongwa) mumasero ekenza. Zvidzidzo zvakaratidza kugona kwe nigericin kudzivirira kukura kwemasero ekenza, kukonzera kusashanda zvakanaka kwe mitochondrial, uye kukanganisa nzira dze oncogenic signaling. Izvi zvakawanikwa zvinoratidza kushandiswa kunogona kuitwa kwe nigericin semushonga wekurapa mamwe marudzi ekenza, zvichiratidza basa rayo mukutsvagisa kenza nekugadzirwa kwemishonga. Kunyange zvazvo nigericin ichivimbisa mukutsvagisa kwesainzi nekutsvagisa kenza, basa rayo rehupenyu rine simba rinoda kubatwa nekungwarira uye kushandiswa kwakadzorwa munzvimbo dzemarabhoritari. Vatsvaguri vanoshanda ne nigericin vanofanirwa kutevedzera nhungamiro dzekuchengetedza uye maitiro kuti vave nechokwadi chekuti inochengetedzwa uye inoraswa zvakanaka. Kushanda pamwe chete nenyanzvi dzine ruzivo uye kutevedzera nzira dzakagara dziripo kwakakosha pakushandisa nigericin mukutsvaga kana kuongorora kugona kwayo kurapa mumabasa akasiyana-siyana ekurapa.