Tetrabenzyl Dapagliflozin CAS:2001088-28-2

Yakagadzirwa nenzira dzakasiyana-siyana dze organic, tetrabenzyl dapagliflozin ine magadzirirwo akaomarara emamorekuru akakosha pakushandiswa kwayo kwakasiyana-siyana. Kuvapo kwezvinotsiva benzyl zvina pa dapagliflozin core kunokanganisa reactivity yayo yemakemikari, kunyungudika, uye kudyidzana kwayo ne biological systems. Hunhu uhwu hwemaumbirwo hwakakosha pakunzwisisa chimiro chayo chemishonga uye kugona kwayo kurapa. Mashandisirwo muMishonga. Iyi kemikari ine vimbiso mukutsvagisa mishonga nekuda kwechimiro chayo. Dapagliflozin derivatives, inozivikanwa nebasa rayo se sodium-glucose co-transporter 2 (SGLT2) inhibitors, inoshandiswa mukurapa chirwere cheshuga cherudzi rwechipiri. Kutsiva benzyl pa tetrabenzyl dapagliflozin kunogona kuchinja hunhu hwayo hwe pharmacokinetic kana kuwedzera kusarudza kwayo uye kushanda kwayo seSGLT2 inhibitor. Biological Activity uye Mechanisms Zvidzidzo zvinoratidza kuti dapagliflozin nezvinobviswa zvayo zvine mhedzisiro yazvo yekurapa nekudzivisa SGLT2 mu renal proximal tubules, nokudaro zvichideredza kutorwazve kweglucose mu renal uye kuwedzera kubuda kweglucose mu urinary. Mapoka ebenzyl ari pa tetrabenzyl dapagliflozin anogona kukanganisa simba rayo, kugadzikana kwemetabolism, kana kudyidzana nema receptors asiri echokwadi, zvichikanganisa chimiro chayo chemishonga. Nzira dzekugadzira nekukura Kugadzirwa kwe tetrabenzyl dapagliflozin kunosanganisira maitiro akaomarara e organic anotangira pa dapagliflozin ne benzyl halides kana benzyl alcohols. Kugadzirisa nzira dzekugadzira kwakakosha kuti uwane kuchena kwakanyanya uye goho, zvakakosha pakushandiswa kwemishonga. Uyezve, kunatsiridza nzira dzekugadzira kunowedzera kugona kukura, kushanda zvakanaka, uye kugara kwenguva refu mukugadzirwa kwemishonga. Tsvagiridzo yazvino uye Nzira dzeramangwana Kuedza kwekutsvaga kwazvino kunotarisa pakutsvaga kugona kwe tetrabenzyl dapagliflozin kupfuura kurapwa kwechirwere cheshuga, kusanganisira kushandiswa kwayo muzvirwere zvemwoyo kana matambudziko emetabolism. Zvidzidzo zveramangwana zvinogona kuongorora shanduko kuchimiro chayo kuti ivandudze bioavailability, kuderedza migumisiro, kana kunanga dzimwe nzira dzekurapa. Miedzo yekiriniki uye zvidzidzo zve preclinical zviri kuenderera mberi kuti zviongorore kuchengetedzeka kwayo, kushanda kwayo, uye mhedzisiro yenguva refu. Mhedziso Mukupedzisa, tetrabenzyl dapagliflozin inomiririra chinhu chakakosha mukutsvagisa kwemishonga nemakemikari nekuda kwechimiro chayo chakasiyana uye mashandisirwo anogona kuitwa ekurapa. Kubatanidzwa kwemapoka mana e-benzyl muchirongwa chedapagliflozin kunoratidza hunyanzvi hwayo hwekushanda nesimba uye kugona kwayo kushandisa mishonga, kunyanya muzvirwere zvakaita sechirwere cheshuga cherudzi rwechipiri. Kufambira mberi kwekutsvaga nezvehunhu hwayo hwemakemikari, kudyidzana kwayo nehupenyu, uye nzira dzekugadzira kwakakosha pakuwedzera kugona kwayo kurapa uye kuwedzera mashandisirwo ayo mukurapa kwekiriniki.