1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile inoita basa guru sechikamu chepakati mukugadzirwa kwemakemikari akaomarara, anoshanda mumuviri ane mukana wekushandiswa mumishonga. Kubatanidzwa kwayo mumamorekuru kunogonesa vaongorori kutsvaga mishonga mitsva inotarisa nzvimbo dzakasiyana-siyana dzekurapa dzakadai sekinase inhibitors, fluorescent probes, kana mashandisirwo emakemikari ezvinhu. Kuvapo kwe pyrazole core neboka re dioxaborolane kunounza reactivity chaiyo uye pharmacophoric properties, zvichiita kuti ive yakakosha mukutsvagisa chemistry yemishonga. Mukuedza kuwana mishonga, iyi compound inogona kushanda senzvimbo yekutanga yekugadzira mishonga inogona kushandiswa, ichishandisa maitiro ayo ekugadzirisa mashandiro ebhayoloji uye pharmacokinetic properties. Pamusoro pezvo, boka rebasa re dioxaborolane rinopa mikana yekuwedzera kubviswa uye cross-coupling chemistry, zvingangotungamira mukuvandudzwa kwemamorekuru matsva ane hunyanzvi hwakavandudzwa hwebhayoloji uye hunyanzvi hwakavandudzwa hwe pharmacokinetic profiles. Uyezve, munzvimbo dzedzidzo nedzemaindasitiri, vaongorori vanogona kushandisa chivakwa ichi kugadzirira maraibhurari emhando dzakasiyana dzezvinhu zvinogadzirwa kubva muzvinhu izvi kuti zviitwe muzvidzidzo zvehukama hwemaumbirwo nemabasa, zvichibatsira kuziva makemikari emutobvu ane mhedzisiro inodiwa muhupenyu. Basa rayo mukugadzirwa kwemakemikari rinowedzera kugadzirwa kwemishonga inosanganisa mishonga uye kugadzirwa kwenzira itsva dzekugadzira, zvichiratidza kushanda kwayo kwakakura muzvidzidzo zvesainzi. Kazhinji, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile inoita basa guru mukutsvaga kuwanikwa kwemishonga mitsva uye kutsvagisa kwemakemikari, ichipa chikuva chekugadzirwa kwemamorekuru akasiyana-siyana anoshanda nehupenyu uye mishonga inosanganisa mishonga.