4-Nitrophenyl Beta-D-glucuronide CAS:10344-94-2

Kuonekwa kwe β-glucuronidase activity: 4-NPBG inowanzo shandiswa se chromogenic substrate kuongorora kuvapo uye kushanda kwe β-glucuronidase mumhando dzakasiyana dze biological samples. Iyi enzyme inocheka glycosidic bond ye 4-NPBG, ichigadzira 4-nitrophenol, iyo inogona kuyerwa uchishandisa spectrophotometry.

Zvidzidzo zvekushandiswa kwemishonga: Sezvo β-glucuronidase ichiita basa guru mukushandiswa kwemishonga uye xenobiotics, 4-NPBG inogona kushandiswa kuongorora mashandiro eiyi enzyme muzvidzidzo zvekushandiswa kwemishonga. Inobatsira kunzwisisa huwandu uye kinetics ye glucuronidation reactions, izvo zvakakosha pakubviswa kwemishonga uye kuwanikwa kwayo mumuviri.

Zvidzidzo zveToxicology: Mamwe macompound echepfu anogona kugayiwa uye kuburitswa muchimiro cheglucuronide conjugates. Nekushandisa 4-NPBG se substrate, vaongorori vanogona kuongorora mashandiro eβ-glucuronidase mumatishu akasiyana kana mitsetse yemasero kuti vaongorore chepfu inogona kuitika kana mhedzisiro yakaipa yemakemikari.

Kuongororwa kwekiriniki: Kuyerwa kwemabasa eβ-glucuronidase uchishandisa 4-NPBG kunogona kushandiswa muzvipatara kuongorora zvimwe zvirwere kana mamiriro ezvinhu. Kuwanda kusina kujairika kana kushanda kweβ-glucuronidase kunogona kuratidza mamwe matambudziko emajini, kusashanda zvakanaka kwechiropa, kana kenza.