Acetylthiocholine iodide CAS:1866-15-5

Acetylthiocholine iodide inonyanya kushandiswa se substrate yekuyera mashandiro eenzyme acetylcholinesterase (AChE). AChE ndiyo inokonzera kupwanya neurotransmitter acetylcholine mutsinga dzetsinga. Kuwedzera acetylthiocholine iodide mumusanganiswa we reaction une AChE kunotungamira mukugadzirwa kwethiocholine neacetate.

Maitiro acho anogona kuonekwa nekuwedzera chiratidzo che colorimetric kana fluorometric chinoita zvakafanana ne thiocholine. Mwero wekugadzirwa kwemavara kana fluorescence unoenderana zvakananga nebasa re AChE mumuenzaniso. Izvi zvinoita kuti acetylthiocholine iodide ive chishandiso chakakosha chekuyera mashandiro e AChE mumienzaniso yakasiyana-siyana yehupenyu, kusanganisira matishu, masero, uye ropa.

Kuyerwa kwebasa reAChE uchishandisa acetylthiocholine iodide kunoshandiswa zvakanyanya muzvidzidzo zvekutsvagisa zvine chekuita nehurongwa hwecholinergic, zvirwere zvetsinga, uye kusangana nemamwe makemikari kana mishonga inogona kukanganisa basa reAChE. Inogona zvakare kushandiswa sechishandiso chekuongorora chekuona zvinodzivirira AChE, izvo zvinonyanya kufarira kugadzirwa kwemishonga yezvirwere zvakaita seAlzheimer's neParkinson's.

Pamusoro pekushandiswa mukuyedza ma enzyme, acetylthiocholine iodide inogonawo kushandiswa se substrate yema biosensors akavakirwa paAChE. Aya biosensors akagadzirwa kuti aone uye aone kuvapo kwezvinhu zvinogona kudzivirira kushanda kweAChE, zvakaita se organophosphate pesticides kana tsinga.