Candesartan CAS:139481-59-7 Mugadziri Mutengesi Mufananidzo Wakaratidzwa

Candesartan CAS:139481-59-7 Mugadziri wezvigadzirwa

Candesartan imupikisi we angiotensin II receptor I (AT1), IC50s=1.12 uye 2.86 nM yebovine adrenal cortex uye rabbit aorta zvakateerana. Inodzivirira kusungwa kweangiotensin II-induced contraction ye rabbit aortic strips pasina kukanganisa kusungwa kunokonzerwa nezvimwe zvinhu zvakaita se norepinephrine, KCl, serotonin, PGF2α kana endothelin.

Odha kana Kumbira Mutengo

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Kushandiswa uye Mhedzisiro

Candesartan imhando yeAT1 (angiotensin II receptor 1) inopesana. Kusawirirana kwema-angiotensin receptors kunodzivirira kuvharwa kweropa uye kugadzirwa kwealdosterone, zvichikonzera kudzikira kwehuwandu hwemvura nesodium muropa. Inoratidza mhedzisiro yekuderedza BP mumhuka. Inoshandiswa mukurapa kukundikana kwemoyo, sekuderedza BP. Candesartan haikanganisi kugara zvakanaka kwemasero kana kuwanda kwawo asi inowedzera kuratidzwa kweVEGF uye interleukin-8 munzvimbo yakakurirwa yemasero eKU-19-19. Candesartan (0.1 nM) inogona kuderedza mhinduro yepamusoro yekubatwa kweropa kuangiostensin II neinenge 50%.

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Mamwe Mashoko:

Kuumbwa	C24H20N6O3
Kuyedza	99%
Chitarisiko	Upfu chena
Nhamba yeCAS	139481-59-7
Kurongedza	1KG 25KG
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.