Candesartana Cilexetila CAS:145040-37-5

Candesartan cilexetil iprodrug yeakasimba, inogara kwenguva refu, uye inosarudza angiotensin II mhando 1 receptor AT1 antagonist, candesartan.Iyo inokurumidza hydrolyzed kune candesartan panguva yekutorwa kwegastrointestinal.Mushure me hydrolysis ye candesartan cilexetil ku candesartan panguva yekutorwa kwegastrointestinal, candesartan inosarudza kukwikwidza neangiotensin II yekusungwa kweangiotensin II receptor subtype 1 AT1 muvascular smooth muscle, ichivharira angiotensin II-mediated vasoconstriction uye inducing vasodilatation.Mukuwedzera, kupesana kweAT1 mu adrenal gland inhibits angiotensin II-inokurudzirwa aldosterone synthesis uye secretion neadrenal cortex;sodium uye mvura excretion inowedzera, inoteverwa nekuderedzwa kwehuwandu hweplasma uye kuwedzera kweropa.