Leflunomide CAS:75706-12-6 Manufacturer Supplier Featured Image

Leflunomide CAS:75706-12-6 Mugadziri Wekutengesa

Leflunomide chirwere chemuromo-chinowanikwa-chinogadzirisa antirheumatic drug uye chakatangwa seArava muU.SA chekurapa rheumatoid arthritis (RA);ndiwo mushonga wekutanga uye wega unofanirwa kuratidzwa kuti unonoke kukuvadzwa kwemajoini eRA, saka kugadzirisa kushaikwa kwekurapa kusingakwane.Leflunomide ipro-drug inokurumidza uye inenge yakanyatsogadziriswa (half-life, <60 maminitsi) ichitevera nemuromo. kutungamira kune teriflunomide, iyo pharmacologically inoshanda α-cyanoenol metabolite.

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Leflunomide haishande, asi teriflunomide inhibits pyrimidine de novo synthesis pamitengo yakaderera yekurapa nekudzivisa dihydroorotate dehydrogenase (iyo chiyero-inogadzirisa enzyme yekugadzirwa kweUMP), kuderedza DNA neRNA synthesis, uye kusunga kutenderera kwesero kuwedzera uye kugadzirwa kwemasoja ekudzivirira chirwere.Kuderedzwa kwe dihydroorotate kuita orotate kunoitika panguva imwe chete nekuderedzwa kweiyo cofactor, ubiquinone (coenzyme Q).Iyo inhibition ye dihydroorotate dehydrogenase ne teriflunomide inoratidza isina kukwikwidza uye isina kukwikwidza kinetics.Kutungamirirwa kwe leflunomide kune varwere vane rheumatoid arthritis inoguma nekubviswa kunofambira mberi kwemasero eB uye pasi-mutemo wekudzivirira muviri.

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Composition	C12H9F3N2O2
Assay	99%
Chitarisiko	Upfu chena
CAS Nha.	75706-12-6
Packing	25KG
Sherufu Hupenyu	2 years
Storage	Chengetedza munzvimbo inotonhorera uye yakaoma
Certification	ISO.