Leflunomide CAS:75706-12-6 Mugadziri weMugadziri

Leflunomide mushonga unoshandiswa pakurapa rheumatoid arthritis unowanikwa nemuromo uye wakatangwa kuUS seArava kurapa rheumatoid arthritis (RA); ndiwo mushonga wekutanga uye wega wakaratidzwa kuderedza kukuvara kwemajoini eRA, saka kugadzirisa zvinodiwa zvekurapa zvisina kuzadzikiswa. Leflunomide mushonga unobatsira kugaya nekukurumidza uye kusvika pakupera kwemuviri (hafu yehupenyu, pasi pemaminitsi makumi matanhatu) mushure mekunwa teriflunomide, iyo metabolite inoshanda mumishonga inoshanda mu α-cyanoenol.

Odha kana Kumbira Mutengo

Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Kushandiswa uye Mhedzisiro

Leflunomide haishande, asi teriflunomide inodzivirira kugadzirwa kwepyrimidine de novo pamishonga yakaderera yekurapa nekudzivisa dihydroorotate dehydrogenase (enzyme inosarudza mwero wekugadzirwa kweUMP), kuderedza kugadzirwa kweDNA neRNA, uye kumisa kutenderera kwekukura kwemasero uye kugadzirwa kwema antibodies. Kuderedzwa kwe dihydroorotate kuita orotate kunoitika panguva imwe chete nekuderedzwa kwe cofactor yayo, ubiquinone (coenzyme Q). Kudziviswa kwe dihydroorotate dehydrogenase ne teriflunomide kunoratidza kinetics isingakwikwidzane uye isingakwikwidzane. Kupiwa kwe leflunomide muvarwere vane rheumatoid arthritis kunoguma nekubviswa zvishoma nezvishoma kwemasero eB uye kudzikiswa kwemaitiro ekudzivirira muviri.

Muenzaniso weChigadzirwa

Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	C12H9F3N2O2
Kuyedza	99%
Chitarisiko	Upfu chena
Nhamba yeCAS	75706-12-6
Kurongedza	25KG
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.