Linezolid CAS:165800-03-3

Linezolid inoshandiswa zvakanyanya mukurapa hutachiona hwakakomba hweGram-positive husingaurayiwi nemamwe maantibiotic. Inowanzo kunyorerwa hutachiona hweganda nenyama yakapfava, pneumonia, bacteremia, uye hutachiona hwemapfupa hunokonzerwa neMRSA, VRE, nedzimwe hutachiona husingaurayiwi nemishonga yakawanda. Kugona kweLinezolid kurwisa hutachiona uhu hwakaoma kurapa kunoita kuti ive mushonga unokosha mukurwisa hutachiona hwakaoma. Muzvipatara, linezolid inowanzo shandiswa pakurapa hutachiona hwenosocomial uye pneumonia inokonzerwa nehutano nekuda kwekushanda kwayo kwakakura uye kuchengetedzeka kwakanaka. Mushonga wayo unonwiwa unobvumira kurapwa kwemamwe hutachiona kunze kwechipatara, zvichipa varwere kurapwa kunoshanda kurwisa hutachiona hwebhakitiriya hune matambudziko. Uyezve, linezolid inoshandiswa mukurapa TB nedzimwe hutachiona hwemycobacterial sechikamu chemishonga inosanganiswa. Maitiro ayo akasiyana ekushanda uye kupinda kwakanaka kwenyama kunoita kuti ive chinhu chakakosha pakurapa TB isingarapike nemishonga uye hutachiona hwemycobacterial husingarapike mishonga. Munzvimbo dzekutsvagisa, linezolid inoshandiswa senzira yekuyedza hutachiona hwehutachiona kuti iongorore kunzwisiswa kwebhakitiriya kune mushonga uyu. Nekuona huwandu hushoma hwekudzivirira (MIC) hwe linezolid kurwisa mabhakitiriya chaiwo, vaongorori vanogona kutungamira nzira dzakakodzera dzekurapa uye kutarisa maitiro ekudzivirira. Kazhinji, linezolid inoita basa rakakosha mukurapa hutachiona hweGram-positive, ichipa vanachiremba sarudzo yakasimba uye yakavimbika yekurapa hutachiona husingarapike nemishonga. Kushanda kwayo kwakasimbiswa, kushivirira, uye kushanduka-shanduka kunoita kuti ive chikamu chakakosha mukurwisa zvirwere zvinotapukira, kunyanya izvo zvinokonzerwa nemabhakitiriya asingarapike nemishonga yakawanda.