Natamycin/Pimaricin CAS:7681-93-8 Mugadziri weMugadziri

Pimaricin (inozivikanwawo se natamycin, INN) ndeyemushonga wefungus unowanikwa zvakasikwa unobva mukuviriswa kwebhakitiriya reStreptomyces natalensis. Imhando yefungus ye macrolide polyene inoshandiswa kurapa fungus keratitis, inova mhando yehutachiona hwemaziso. Mukurapa, inogona kushandiswa kurapa mhando dzakasiyana dzehutachiona hwefungus hunokonzerwa neCandida, Aspergillus, Cephalosporium, Fusarium, uye Penicillium. Muindasitiri yechikafu, inogona kushandiswa semushonga wekuchengetedza fungus kudzivirira kukura kwayo. Maitiro ayo ndeekubatanidza kuergosterol muplasma membrane yefungus, zvichidzivisa maitiro e ergosterol-dependent fusion ye vacuoles uye membrane fusion, zvichidzivirira kukura kwefungus. Inodzivirirawo kutakurwa kweamino acid neglucose kuburikidza nekudzivisa mapuroteni ekutakura membrane.

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Kushandiswa uye Mhedzisiro

Pimaricin imhando ye macrocyclic tetraene yakatanga kutorwa kubva kuStreptomyces natalensis muna 1957. Pimaricin inoratidza kushanda kwakakura kwefungus kurwisa mbiriso nefungus dzakapfava nekusunga zvakananga ku ergosterol kudzivirira kukura kwefungus. Kusiyana ne polyenes dzakabatana, nystatin ne filipin, pimaricin haichinje kupenya kwe plasma membrane. Pimaricin inoshandiswa muindasitiri yezvekudya kurapa chizi pamusoro semushonga unodzivisa kuumbwa kwefungus. Natamycin mushonga unorwisa utachiona we polyene unogadzira mishonga. Natamycin hainyungudike zvakanaka mumvura uye haipindi mu cornea epithelium isina kusimba. Natamycin ndiyo yega mushonga unorwisa fungus wakatenderwa kushandiswa paziso uye ndiyo chete mushonga wemaziso unowanikwa kutengeswa wekurapa fungus keratitis. Natamycin, inozivikanwawo se pimaracin, ndeyemhuri ye polyene yemishonga inorwisa fungus; (boka remishonga inorwisa fungus inotarisa uye inosunga ku eukaryotic sterols uye kunyanya ergosterol), uye ichikamu chechipiri cheStreptomyces natalensis.

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Kurongedza Chigadzirwa:

Mamwe Mashoko:

Kuumbwa	C33H47NO13
Kuyedza	99%
Chitarisiko	Upfu hwakachena kusvika husina kuchena
Nhamba yeCAS	7681-93-8
Kurongedza	25KG
Hupenyu hweSherufu	makore maviri
Kuchengetera	Chengeta munzvimbo inotonhorera uye yakaoma
Chitupa	ISO.