Letrozole chikamu chechizvarwa chitsva che aromatase inhibitors anosarudza zvakanyanya uye inogadzirwa nemhando yebenzotriazole derivative.Letrozole inhibits aromatase kudzikisa estrogen mazinga, nokudaro kudzivirira estrogen kubva mukukurudzira bundu kukura.Yayo mu vivo chiitiko ndeye 150-250 nguva yakasimba kupfuura yechizvarwa chekutanga aromatase inhibitor Amarante.Sezvo yakanyanya kusarudzwa, haizokanganisa glucocorticoid, mineralocorticoid uye thyroid mabasa;kunyangwe pamadosi akakwirira, haizove nechero inhibiting mhedzisiro pane adrenal corticosteroid secretion, ichipa iyo yakanyanya kurapwa index.