PhentolamineMesylate CAS:65-28-1

Phentolamine mesylate inoshanda mabasa akasiyana-siyana akakosha mukurapa uye mukutsvaga. Semushonga une simba wekuderedza ropa uye wekuderedza BP, inoshandiswa mukurapa emergency BP, kunyanya kana paine dambudziko re pheochromocytoma, uko kuderedzwa kweBP nekukurumidza kwakakosha. Inobatsirawo mukurapa zviitiko zveBP zvinokonzerwa ne iatrogenic catecholamine panguva yekuvhiyiwa nedzimwe nzira dzekurapa. Mukurapa mazino, phentolamine mesylate inoshandiswa semushonga wekurapa marwadzo emunzvimbo, ichibatsira mukutarisira anesthesia yenyama yakapfava mushure mekuita kwemazino kunosanganisira anesthetics yemunzvimbo ine vasoconstrictor senge epinephrine. Mhedzisiro yayo yekuderedza ropa inobatsira mukuderedza kudzikamiswa kweropa remunzvimbo uye kukurumidzisa kudzoreredzwa kweropa munyama. Uyezve, mushonga uyu unoshandiswa mukuita kwekuongorora zvakaita sekudzivirira nekurapa dermal necrosis inokonzerwa nekuwedzera mishonga inoshanda muropa, kuve nechokwadi chekuti ropa rinoyerera zvakanaka munyama. Pamusoro pezvo, inobatanidzwa muzvidzidzo zvekutsvagisa nemiedzo yekiriniki inoongorora mashandisirwo ayo anogona kuitwa mumamiriro ezvinhu ane chekuita nekusakwana kwetsinga dzeropa, kusagadzikana kwesimba remurume, uye chiitiko chaRaynaud, zvichibatsira mukufambira mberi mukurapa kwemwoyo nekwemudumbu. Basa rePhentolamine mesylate rinoshandawo mukuyedza sechishandiso mukutsvagisa kwemishonga nemuviri, zvichibatsira mukuferefeta mashandiro eadrenergic receptor, mhinduro dzetsinga dzeropa, uye kushandurwa kwebasa retsinga dzeropa. Kugona kwayo kuvharira adrenergic receptors uye kukanganisa tsinga dzeropa kunobatsira mukunzwisisa mashandiro etsinga dzemwoyo uye kukura kwenzira dzekurapa dzinotarisa nzira dzechiratidzo cheadrenergic. Kazhinji, mashandisirwo akasiyana-siyana ephentolamine mesylate anoratidza kukosha kwayo mukurapa kwekiriniki, mazino, tsvakurudzo, uye kugadzirwa kwemishonga, zvichisimbisa kugona kwayo kubatsira mukutarisira kwakanaka kwezvirwere zvemwoyo uye kufambira mberi kweruzivo rwesainzi rune chekuita nebasa readrenergic receptor uye kutonga kwetsinga dzeropa.