4-Nitrophenyl Beta-D-glucuronide CAS:10344-94-2

Kuonekwa kwe β-glucuronidase basa: 4-NPBG inowanzoshandiswa sechromogenic substrate kuongorora kuvapo uye basa re β-glucuronidase mumhando dzakasiyana-siyana dzehupenyu.Iyo enzyme inobvisa glycosidic bond ye4-NPBG, ichigadzira 4-nitrophenol, inogona kuyerwa uchishandisa spectrophotometry.

Zvidzidzo zvemetabolism yezvinodhaka: Sezvo β-glucuronidase ichiita basa rakakosha mumetabolism yezvinodhaka uye xenobiotics, 4-NPBG inogona kushandiswa kuongorora basa reiyo enzyme muzvidzidzo zvemetabolism yezvinodhaka.Inobatsira mukunzwisisa huwandu uye kinetics ye glucuronidation maitiro, ayo akakosha pakubvisa zvinodhaka uye bioavailability.

Zvidzidzo zveToxicology: Mamwe makomisheni ane chepfu anogona kugadzirwa uye kuburitswa muchimiro cheglucuronide conjugates.Nokushandisa 4-NPBG se substrate, vatsvakurudzi vanogona kuongorora basa re β-glucuronidase mumhando dzakasiyana-siyana kana mitsara yemasero kuti vaongorore zvingangoita huturu kana migumisiro yakaipa yemakemikari.

Clinical diagnostics: Chiyero chebasa re β-glucuronidase uchishandisa 4-NPBG inogona kushandiswa mumakiriniki ekuongorora zvimwe zvirwere kana mamiriro.Maitiro asina kujairika kana chiitiko che β-glucuronidase chinogona kuratidza kumwe kukanganiswa kwemajini, kusashanda kwechiropa, kana kenza.