Fmoc-Asp(OBut)-OSu CAS:78553-23-8

Fmoc-Asp(OBut)-OSu inoshanda sechishandiso chinoshanduka-shanduka mukugadzirwa kwepeptide, kunyanya mukugadzira mapeptide ane aspartic acid nemazvo. Boka rinodzivirira Fmoc rinodzivirira boka reamino, richivimbisa maitiro akasarudzwa panguva yekubatanidza peptide, nepo boka reO-butyl richiwedzera imwe layer yekudzivirira kuboka recarboxyl. Mashandiro eOSu ester anobatsira kuumbwa kweamide bond inoshanda uye inosarudza panguva yekubatanidza peptide. Vaongorori vanoshandisa zvakanyanya Fmoc-Asp(OBut)-OSu mukugadzira mapeptide ekushandisa akasiyana-siyana, kusanganisira kugadzira mishonga, biomaterials, uye kugadzira mapeptide anoshanda ane chimiro chakananga. Kuenderana kwayo nemaitiro akajairwa ekugadzira peptide, mune ese ari maviri solid-phase uye solution-phase strategies, kunowedzera kushanduka kwayo mumabasa akasiyana-siyana ekutsvagisa. Kubviswa kwakadzorwa kwemapoka anodzivirira kunobvumira kuiswa kweaspartic acid mu peptide sequences, kuwedzera huwandu hwemapeptide anogona kugadzirwa. Uyezve, Fmoc-Asp(OBut)-OSu inowana rubatsiro mukugadzira mapeptide ekutsvagisa kweproteomics nekudzidza maitiro emasero. Kushandiswa kweboka rekudzivirira reO-butyl kunogonesa kushandiswa kwakanyatsojeka kweaspartic acid reactivity, uye boka reOSu ester rinogonesa bioconjugation uye labeling yemapeptides. Mukupfupisa, Fmoc-Asp(OBut)-OSu inomira sechishandiso chakakosha uye chisingakoshi mu peptide chemistry, ichipa simba vaongorori kuti vaongorore uye vagadzirise aspartic acid reactivity kune akasiyana mashandisirwo esainzi, kunyanya kutarisa mapeptide ane functionalization yakawedzerwa kuburikidza neboka reOSu ester.